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Although Bupropion is not metabolized by cytochrome P450IID6 (CYP2D6), there is the potential for drug-drug interactions when Bupropion is co-administered with drugs metabolized by this isoenzyme (see PRECAUTIONS: Drug Interactions). The extent of protein binding of the hydroxyBupropion metabolite is similar to that for Bupropion, whereas the extent of protein binding of the threohydroBupropion metabolite is about half that seen with Bupropion. While the mechanism of action of Bupropion, as with other antidepressants, is unknown, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms. 5%, a finding consistent with the extensive metabolism of Bupropion. However, it has been demonstrated in an antidepressant screening test in mice that hydroxyBupropion is one half as potent as Bupropion, while threohydroBupropion and erythrohydroBupropion are 5-fold less potent than Bupropion. The times to peak concentrations for the erythrohydroBupropion and threohydroBupropion metabolites are similar to that of the hydroxyBupropion metabolite.
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